Abstract:Objective:To investigate and analyze the correlations among illness uncertainty, pain, anxiety, and quality of life in patients with trigeminal neuralgia. Methods:From October 2024 to December 2025, 62 patients diagnosed with trigeminal neuralgia were conveniently recruited from the Pain Department of the First Affiliated Hospital of Anhui Medical University. The following assessment tools were used: a general information questionnaire, the Mishel Uncertainty in Illness Scale for Adults (MUIS-A), the Visual Analogue Scale (VAS) for pain assessment, the Self-rating Anxiety Scale (SAS), and the 36-Item Short Form Health Survey (SF-36). Correlation analyses were performed between illness uncertainty, pain scores, anxiety scores, and quality of life scores. Results:A total of 60 valid questionnaires were collected, with an effective response rate of 96.8%. The total illness uncertainty score of patients with trigeminal neuralgia was (110.30 ± 24.96), indicating a moderate-to-high level of uncertainty. The pain assessment scores ranged from (5.75 ± 0.44) to (8.50 ± 1.11), suggesting moderate-to-severe pain. The anxiety scores ranged from (57.67 ± 1.53) to (75.33 ± 2.96). Illness uncertainty was positively correlated with pain intensity (r = 0.627, P < 0.01) and with anxiety levels. The scores across the quality of life domains ranged from (30.42 ± 17.58) to (70.42 ± 15.60), and illness uncertainty showed a negative correlation with quality of life (P < 0.05). Conclusion: Illness uncertainty in patients with trigeminal neuralgia is considerable. Pain-induced anxiety contributes to a decline in quality of life, with more severe pain associated with greater anxiety, worse quality of life, and higher levels of illness uncertainty. Healthcare professionals should implement proactive interventions targeting illness uncertainty in patients with trigeminal neuralgia to improve their health status and enhance their quality of life.