中文版偏头痛治疗优化问卷（mTOQ-C）的跨文化调适及信效度检验

Cross-cultural Adaptation and Validation of the Chinese Version of the Migraine-Treatment Optimization Questionnaire (mTOQ-C)

摘要:

目的： 对偏头痛治疗优化问卷（Migraine-Treatment Optimization Questionnaire, M-TOQ）进行跨文化调适，形成中文版，并系统评价其信效度，同时构建简化版本。 方法： 在取得原作者同意后，依据国际指南完成跨文化调适，形成mTOQ-C19。连续招募就诊于重庆医科大学附属第一医院头痛门诊的偏头痛患者，进行探索性因子分析确定量表的维度区分，检测量表的聚合效度及信度（内部一致性、重测信度），同时构建简化版本（mTOQ-C12与mTOQ-C6）。 结果： 共纳入210名患者（平均年龄39.3±11.4岁，女性占74.3%）进行信效度检验。探索性因子分析提取出“快速反应”、“复发”、“副作用”、“总体评价”四个因子。mTOQ-C19总量表Cronbach’s α为0.917，重测信度为0.943；与成熟的偏头痛评估量表均显著相关（P＜0.01）。经系统条目筛选后形成mTOQ-C12和mTOQ-C6，两者的Cronbach’s α系数分别为0.868和0.735，且与标准量表保持类似的聚合效度和良好的重测信度。 结论：mTOQ-C及其简化版具有良好的信度、效度与文化适应性，可作为评估中国偏头痛患者急性治疗优化程度的可靠工具。

Abstract:

Objective: To conduct cross-cultural adaptation of the Migraine-Treatment Optimization Questionnaire (M-TOQ) into Chinese version (mTOQ-C), systematically evaluate its reliability and validity, and develop simplified versions. Methods: Following approval from the original author, cross-cultural adaptation was performed according to international guidelines, resulting in the mTOQ-C19. Consecutive migraine patients from the headache clinic of the First Affiliated Hospital of Chongqing Medical University were recruited. Exploratory factor analysis (EFA) was used to determine the scale's dimensional structure. Convergent validity and reliability (internal consistency, test-retest reliability) were assessed. Simplified versions (mTOQ-C12 and mTOQ-C6) were subsequently developed. Results: A total of 210 patients (mean age 39.3±11.4 years; 74.3% female) were included for reliability and validity testing. EFA extracted four factors: "Rapid response", "Recurrence", "Side effects", and "Global response" The mTOQ-C19 showed a Cronbach's α of 0.917 and test-retest reliability (ICC) of 0.943. It was significantly correlated with established migraine assessment scales (P<0.01). Through systematic item reduction, the mTOQ-C12 and mTOQ-C6 were formed, demonstrating Cronbach's α coefficients of 0.868 and 0.735, respectively. Both simplified versions maintained comparable convergent validity and good test-retest reliability. Conclusion: The mTOQ-C and its simplified versions exhibit good reliability, validity, and cultural adaptability, serving as reliable tools for assessing the optimization of migraine acute treatment in Chinese patients.