腰椎间盘退变机制研究进展

Research Progress on the Mechanisms of Lumbar Disc Degeneration *

摘要:

腰椎间盘退变(Lumbar disc degeneration,LDD)是常见的临床表现,约40%的慢性下腰痛(Low back Pain,LBP)与LDD直接相关。当前 LBP致残率已位于各类慢性疾病首位,造成了极大的社会、经济和医疗负担。基于此,全面深入阐述腰椎间盘退变机制,为椎间盘退变机制相关研究提供参考,有利于寻找LDD治疗靶点,从而降低LBP发病率。本研究将围绕腰椎间盘发生的炎性、衰老、应力机制展开最新综述,以为理解椎间盘发生机制和治疗提供参照。

Abstract:

Lumbar disc degeneration (LDD) is a common clinical condition, and approximately 40% of chronic low back pain (LBP) cases are directly associated with LDD. Currently, the disability rate attributable to LBP ranks highest among all chronic diseases, imposing a significant social, economic, and healthcare burden. Therefore, a comprehensive and in-depth elucidation of the mechanisms underlying LDD is crucial, as it can provide valuable insights for related research, facilitate the identification of therapeutic targets for LDD, and consequently help reduce the incidence of LBP. This review will focus on the latest advances concerning the inflammatory, aging, and stress-related mechanisms involved in the pathogenesis of lumbar disc degeneration, aiming to offer references for understanding its pathophysiology and developing treatments.