大麻二酚治疗慢性疼痛分子机制及研究进展

MOLECULAR MECHANISMS AND RESEARCH ADVANCES OF CBD IN CHRONIC PAIN MANAGEMENT

摘要:

慢性疼痛是持续超过组织正常愈合时间的疼痛,严重影响病患的生活质量,且易引发焦虑、抑郁等消极情绪及行为,目前仍缺乏标准的生物医学管理和治愈方法。大麻二酚是从大麻植物中提取的大麻素类(萜酚亚类)化合物,具有抗炎、抗抑郁和镇痛等药理作用。本文综述大麻二酚通过多种机制治疗慢性疼痛,例如激活辣椒素受体、5-羟色胺受体1 A受体、过氧化物酶体增殖物激活受体γ、核因子κB、NLRP3炎症小体 、抗氧化应激、内源性大麻素系统等,并且对其他可能机制进一步探究,以期为疼痛提供新的治疗思路。

Abstract:

Chronic pain, defined as pain persisting beyond the normal tissue healing time, significantly impairs patients" quality of life and can trigger negative emotions and behaviors such as anxiety and depression. Currently, there remains a lack of standardized biomedical management and curative approaches. Cannabidiol (CBD) has demonstrated unique potential in the treatment of chronic pain. This review summarizes the diverse mechanisms through which CBD exerts its therapeutic effects on chronic pain, including interactions with the transient receptor potential vanilloid 1 (TRPV1), serotonin 1A receptor (5-HT1A), peroxisome proliferator-activated receptor gamma (PPARγ), nuclear factor kappa B (NF-κB), the NLRP3 inflammasome, as well as its antioxidant effects and modulation of the endocannabinoid system. Furthermore, we explore additional potential mechanisms, aiming to provide novel therapeutic approaches for pain management.