Objective: To summarize the evidence on patient-controlled analgesia (PCA) nursing care for hospitalized patients, providing a reference for evidence-based pain management practices. Methods: A systematic search was conducted in Chinese and English databases for literature on PCA management in hospitalized patients over the past decade. Results: A total of 45 studies were included, comprising 5 guidelines, 6 expert consensus reports, 3 meta-analyses, 11 systematic reviews. The summarized evidence yielded 45 key recommendations. Conclusions: The compiled evidence on PCA for hospitalized patients can serve as a reference for clinical practice. Healthcare professionals are advised to develop pain management protocols based on specific clinical contexts, considering the applicability and feasibility of the evidence.