458例带状疱疹后神经痛的危险因素分析

Analysis of Risk Factors for 458 Cases of Postherpetic Neuralgia

摘要:

研究目的：本研究旨在探究带状疱疹（HZ）患者发生带状疱疹后神经痛（PHN）的相关危险因素。 研究方法：选取2021年1月至2025年4月我院收治的458例带状疱疹患者，根据其疱疹愈合后是否出现后神经痛将其分为带状疱疹后神经痛组（PHN=155例）和非后神经痛组（非PHN=303例），收集其常见临床资料，通过单因素及多因素Logistic回归分析HZ患者并发PHN的独立危险因素， 研究结果：单因素Logistic回归分析显示，年龄、特殊部位疱疹、带状疱疹病程、视觉模拟评分(VAS)、皮肤损伤严重程度、糖化血红蛋白(HbA1c)水平及体温升高>1℃是带状疱疹（HZ）患者发生带状疱疹后神经痛（PHN）的危险因素，具有统计学意义；多因素Logistic回归分析显示年龄、带状疱疹病程、特殊部位疱疹、视觉模拟评分（VAS）、皮损严重程度、体温升高＞1℃是PHN的独立危险因素。 结论：年龄、带状疱疹病程、特殊部位疱疹、视觉模拟评分（VAS）、皮损严重程度、体温升高＞1℃是PHN的独立危险因素。 【关键词】：带状疱疹后神经痛；危险因素；带状疱疹

Abstract:

Objective: This study aims to investigate the risk factors associated with postherpetic neuralgia (PHN) in patients with herpes zoster (HZ). Methods: A total of 458 HZ patients admitted to our hospital from January 2021 to April 2025 were selected and divided into a postherpetic neuralgia group (PHN = 155 cases) and a non-postherpetic neuralgia group (non-PHN = 303 cases) based on whether they developed neuralgia after herpes healing. Common clinical data were collected, and univariate and multivariate logistic regression analyses were conducted to identify independent risk factors for PHN in HZ patients. Results: Univariate logistic regression analysis revealed that age, herpes in special locations, duration of herpes zoster, visual analog scale (VAS) score, severity of skin lesions, glycated hemoglobin (HbA1c) level, and body temperature increase >1°C were statistically significant risk factors for PHN in HZ patients. Multivariate logistic regression analysis identified age, duration of herpes zoster, herpes in special locations, VAS score, severity of skin lesions, and body temperature increase >1°C as independent risk factors for PHN. Conclusion: Age, duration of herpes zoster, herpes in special locations, VAS score, severity of skin lesions, and body temperature increase >1°C are independent risk factors for PHN.