骶神经脉冲射频联合奇神经节射频热凝治疗阴部神经痛的疗效

Efficacy of Sacral Nerve Pulse Radiofrequency Modulation Combined with Ganglion Impar Radiofrequency Thermocoagulation in the Treatment of Pudendal Neuralgia

摘要:

目的:本研究结合了骶神经脉冲射频与奇神经节射频热凝技术,旨在探讨骶神经脉冲射频联合奇神经节射频热凝治疗阴部神经痛的疗效。方法:研究纳入了符合Nantes诊断标准的62例阴部神经痛患者,对照组仅接受常规药物治疗与奇神经节射频热凝,而联合组则在此基础上加用骶神经脉冲射频。采用卡诺夫斯基表现状态(karnofsky scores,KS)、NRS数字评分量表(numerical rating scale,NRS)以及焦虑抑郁量表(hospital anxiety and depression scale,HADS)作为主要观察指标,以全面评估治疗效果及患者生活质量改善情况。结果: 联合组患者的KS评分的提高显著高于对照组,表明联合组治疗后患者的整体治疗情况和生活质量得到了显著改善(P＜0.01)；治疗后第2周,第4周及第3个月的时间点上,联合组的NRS评分显著低于对照组,差异有统计学意义(P＜0.01)；同时两组在治疗后的有效率及显效率上也存在差异,联合组在治疗后的显效率明显高于对照组,差异有统计学意义(P＜0.05)；此外,联合组患者的HADS评分也显著低于对照组,差异具有统计学意义(P<0.01)。安全性方面,两组患者在治疗过程中均未出现严重不良反应,联合组仅少数患者报告了轻微针刺不适,均在可接受范围内,未影响治疗进程。结论:骶神经脉冲射频联合奇神经节射频热凝治疗阴部神经痛展现出了显著的疗效,不仅在缓解疼痛、改善生活质量方面优于单一治疗,且安全性良好。

Abstract:

Object:This study combined sacral nerve pulse radiofrequency modulation with ganglion impar radiofrequency thermocoagulation to investigate the efficacy of this combined treatment for pudendal neuralgia. Methods:Sixty-two patients with pudendal neuralgia who met the diagnostic criteria were included in the study. The control group received only conventional medication and ganglion impar radiofrequency thermocoagulation, while the combination group received additional sacral nerve radiofrequency modulation. The Karnofsky Performance Status (KPS), Numerical Rating Scale (NRS), Hospital Anxiety and Depression Scale (HADS)were used as the primary observation indicators to comprehensively assess the treatment effect and improvement in patients" quality of life. Results:The results showed that the improvement in KPS scores was significantly higher in the combination group compared to the control group, indicating a significant improvement in the overall treatment situation and quality of life of patients in the combination group after treatment (P<0.01). At the time points of 2 weeks, 4 weeks, and 3 months after treatment, the NRS scores in the combination group were significantly lower than those in the control group, with a statistically significant difference (P<0.01). Additionally, there were differences in the effective rate and marked effective rate between the two groups after treatment, with the marked effective rate in the combination group being significantly higher than that in the control group, and the difference was statistically significant (P<0.05). Furthermore, the HADS scores in the combination group were also significantly lower than those in the control group, with a statistically significant difference (P<0.01). In terms of safety, no serious adverse reactions were observed in either group during the treatment process. Only a few patients in the combination group reported mild needle discomfort, which was within an acceptable range and did not affect the treatment process. In conclusion, the combination of sacral nerve pulse radiofrequency modulation and ganglion impar radiofrequency thermocoagulation demonstrates significant efficacy in the treatment of pudendal neuralgia, outperforming monotherapy in terms of pain relief, quality of life improvement, and safety.