肠道菌群在神经病理性疼痛伴发焦虑中的作用研究进展*

Research progress on the role of gut microbiota in neuropathic pain accompanied by anxiety*

摘要:

神经病理性疼痛（neuropathic pain，NP）常伴发焦虑，二者往往相互促进形成疼痛-焦虑的恶性循环，严重影响病人的生活质量。近年来，随着微生物群-肠-脑轴研究的深入进展，越来越多的证据表明肠道菌群通过神经、免疫和内分泌等多条途径参与NP和焦虑的发病过程，并且靶向调控肠道菌群的干预策略在缓解疼痛和焦虑方面也展现出了良好的潜力。然而，目前对肠道菌群参与NP伴发焦虑的具体分子机制仍缺乏系统认识。本文围绕肠道菌群调控NP伴发焦虑的潜在机制进行系统分析，旨在为该类病症的临床治疗提供新思路。

Abstract:

Neuropathic pain (NP) is frequently accompanied by anxiety, and the two conditions often mutually reinforce each other, forming a vicious pain-anxiety cycle that significantly impairs patients' quality of life. In recent years, advances in microbiota-gut-brain axis research have provided increasing evidence that gut microbiota participates in the pathogenesis of both NP and anxiety through neural, immune, and endocrine pathways. Furthermore, intervention strategies targeting gut microbiota modulation have demonstrated promising potential in alleviating pain and anxiety symptoms. However, the specific molecular mechanisms by which gut microbiota contributes to NP accompanied by anxiety remain poorly understood. This review systematically analyzes the potential mechanisms underlying gut microbiota-mediated regulation of NP and associated anxiety, aiming to provide novel insights for the clinical management of this condition.