针灸治疗效应的始动因素:C类多模态伤害感受器*

Peripheral C-polymodal?nociceptors related to initiating factors of acupuncture and moxibustion modulation*

摘要:

针刺和热灸的效用机制一直是中医领域的热门研究课题。随着现代神经生理学、分子生物学和基因编辑技术的快速发展，研究者可通过不同的生物标记技术探究既往无法区分的细胞亚型，这为以分子标记物为切入点探究体表不同类型感受器介导针灸调节效应的作用机制提供了新的研究范式，然而目前针对上述研究进展的系统归纳总结尚且缺乏。本文综述了TRP家族、MRGPR家族等分子标记的C类多模态伤害感受器在针灸镇痛及内脏调节中的作用效应及机制探讨，为与针灸传入相关始动因素的分子特性及功能研究提供思路，也为传统与现代医学的融合发展提供潜在探索方向。

Abstract:

The mechanism of utility of acupuncture and moxibustion has been a popular research topic in the field of traditional Chinese medicine (TCM). With the rapid development of modern neurophysiology, molecular biology and gene editing technology, researchers can explore previously indistinguishable cell subtypes by different biomarker techniques, which provides a new research paradigm to explore the mechanism of action of different types of receptors on the body surface mediating the modulatory effects of acupuncture and moxibustion by using molecular markers as an entry point; however, a systematic summarization of the progress of the above studies is still lacking. In this paper, we reviewed the effects and mechanisms of TRP family, MRGPR family and other molecularly labeled C-polymodal?nociceptors in acupuncture analgesia and visceral regulation, which provide ideas for the molecular characterization and functional study of the initiators related to acupuncture afferents, and also provide potential directions for exploration of the development of the integration of traditional and modern medicine.