Abstract:The 2021 Nobel Laureate in Medicine discovered the cellular mechanical force-sensitive-related receptor Piezo protein in 2010, and the structure, function, and association with disease of Piezo protein have been the focus of research in recent years, and it plays an important role in the regulation of pain collar. It has been found that Piezo is associated with neuropathic pain (NP), which is a mechanosensitive cationic protein, whose activation induces cation influx, changes the concentration of ions inside and outside cells, generates nerve electrical signals, induces sensitization of nerve fibers and related nociceptors, and triggers biochemical reactions inside and outside cells, such as intersynaptic signal transmission of nerve cells, nerve regeneration and immune response of immune cells, all of which have regulatory effects on NP. Although the regulatory mechanism of Piezo protein and NP has been studied by scholars, there are still many gaps and limitations in the current research, and it is difficult to accurately grasp the specific path of the development of Piezo protein in NP. Therefore, the purpose of this article is to systematically review the latest research progress of Piezo in the regulation of NP, and propose that Piezo protein is expected to become a new target for the treatment of NP, which will open up a new path for the research and development of potential molecularly targeted analgesic drugs for NP, and also provide more solid theoretical support for acupuncture in the treatment of NP.
