Abstract:Machine learning has emerged as a potent technique for constructing models through the analysis of extensive datasets, facilitating tasks such as data classification, integration, assessment, and forecasting. Its application within pain medicine has demonstrated significant promise, particularly in conjunction with neuroimaging techniques, which have paved the way for novel methodologies in the objective measurement of pain and the customization of treatment strategies, while also enhancing our understanding of the neurobiological underpinnings of pain. Despite the breadth of research in this domain, there is a notable absence of interconnectedness among studies and a deficiency in comprehensive syntheses of the literature, resulting in a fragmented understanding among the scientific and clinical communities. This review synthesizes the current state of machine learning applications in pain medicine, addresses the prevailing challenges, and examines future directions, aiming to provide a structured overview for researchers and clinicians, and to lay the groundwork for continued investigation and advancement of machine learning techniques in the field.