卒中后中枢性疼痛发病机制及非药物治疗研究进展

Pathogenesis and Nonpharmacological Treatment of Central Post-stroke pain

摘要:

卒中后中枢性疼痛 (central post-stroke pain, CPSP) 是一种脑卒中后致残率、致死率较高的中枢性神经病理性疼痛综合征，以自发性疼痛、痛觉过敏、痛觉超敏和感觉异常为主要临床表现。CPSP的发病机制尚未完全明确，药物治疗效果也并不尽如意。近年来，CPSP发病机制和非药物治疗的相关研究进展迅猛。本文就CPSP临床表现、诊断，尤其是其发病机制及非药物治疗研究进展等方面进行阐述，以提高临床医师对CPSP的认知。

Abstract:

Central post-stroke pain (CPSP), a central neuropathic pain syndrome which occurs after a cerebrovascular accident and has a high rate of disability and death, is characterized by spontaneous pain, allodynia, hyperalgesia and paraesthesia. The underlying mechanisms of CPSP have not been well understood, and the effect of drug treatment is not satisfactory. In recent years, the research on the pathogenesis and nonpharmacological treatment of CPSP has made rapid progress. This article reviews the clinical manifestations, diagnosis, especially the pathogenesis and nonpharmacological treatment of CPSP, in order to improve clinicians' understanding of CPSP.