神经病理性疼痛与认知功能障碍共病的细胞和分子机制研究进展

Progress of comorbid study on cellular and molecular mechanisms of neuropathic pain and cognitive dysfunction

摘要:

认知功能障碍是神经病理性疼痛的并发症之一,主要表现为注意力、记忆力和判断力下降,严重影响患者的生活质量。然而,目前神经病理性疼痛和认知功能障碍共病的潜在机制尚未完全明确,因此临床上治疗手段较为有限。神经病理性疼痛会导致与认知相关的神经细胞与神经胶质细胞结构、功能以及相关神经递质的释放发生一系列的改变。本文就既往研究中神经病理性疼痛与认知功能障碍共病相关的细胞和分子机制进行综述,旨在为未来研究提供新思路。

Abstract:

Cognitive dysfunction, one of the comorbidities of neuropathic pain, mainly manifests in the decline of attention, memory and judgment, significantly disrupting patients’ quality of life. The underlying mechanism of comorbidity of neuropathic pain and cognitive impairment nowadays has not been completely clarified and the clinical treatment methods are limited.