Abstract:There is a complex interrelationship between SSD and chronic pain, while pain is a common complaint among SSD patients. The situation poses substantial challenges for pain specialists in efficiently evaluating and accurately diagnosing SSD. Traditional assessment tools often fall short in adequately explaining and addressing these issues, and there is a clinical need for objective and reliable methods to improve the evaluation of SSD patients presenting with pain. Recent studies have shown that autonomic nervous system function alterations are crucial in the onset and maintenance of SSD. Biomarkers reflecting autonomic nervous system status, such as heart rate variability, sympathetic skin response, and abnormal skin temperature distribution patterns, have introduced new directions for the clinical assessment of SSD. This article aims to systematically review the latest research progress of mainstream autonomous nervous system function monitoring techniques in SSD evaluation. We also delve into the advantages and limitations of each method to provide new perspectives and strategies for clinical practice.