Abstract:Abstract: Recent advances in the field of lumbar disc herniation (LDH) pain research have led to significant progress, particularly in the exploration of spontaneous resorption of LDH. Resorption, as a natural process that alleviates clinical symptoms and obviates the need for surgery, has emerged as a key focus in conservative treatment. Existing studies have demonstrated that biological mechanisms, including inflammation, angiogenesis, and matrix degradation, are closely associated with resorption, with immune cell infiltration, inflammatory mediators, and neovascularization playing pivotal roles. Furthermore, factors such as age, sex, and BMI have been identified as critical predictors influencing the incidence of resorption, providing a theoretical foundation for the formulation of individualized treatment strategies. However, several challenges remain, particularly in terms of effectively modulating processes like inflammation and angiogenesis to enhance resorption. Despite some promising findings, current research is often limited by small sample sizes and short-term follow-up, with a lack of large-scale, multi-center clinical validation. Moving forward, precision medicine and big data technologies will serve as essential tools in the development of personalized treatment plans, facilitating the standardization and individualization of non-surgical approaches for LDH. Consequently, future research should focus on elucidating the molecular mechanisms underlying resorption, conducting large-scale, multi-center clinical trials, and integrating advanced technologies to enable precision treatments.
