Abstract:Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has been utilized to treat various neuropsychiatric disorders. In recent years, as understanding of the pain-related brain network mechanisms has deepened, tDCS has gained prominence in pain-related research. However, the analgesic mechanisms of tDCS for chronic pain remain unclear, and its clinical application is still in the early stages; indications, stimulation targets, modulation methods, and long-term efficacy require further investigation. This article reviews the analgesic mechanisms and progress in the application of tDCS for chronic pain management.