SARS-CoV-2感染导致神经病理性疼痛的线粒体机制*

Mitochondrial mechanism of neuropathic pain causedby SARS-CoV-2 infection

摘要:

新型冠状病毒引发的全球大流行,不仅严重影响了人类的呼吸系统健康,同时也对其他系统的潜在影响,尤其是神经系统。研究表明,严重急性呼吸综合征冠状病毒2型(Severe Acute Respiratory Syndrome Coronavirus 2, SARS-CoV-2)感染可能导致外周神经系统损伤,导致神经病理性疼痛产生,其中线粒体功能障碍被认为是一个重要的机制。因此,本文重点综述了SARS-CoV-2感染引发的神经病理性疼痛中涉及的线粒体机制,旨在为探索新冠病毒感染的治疗策略提供新的理论基础。这一研究领域的深入探讨有助于加深对病毒影响神经系统的理解,并为未来疾病治疗和康复提供新的启示。

Abstract:

The global pandemic triggered by novel coronavirus has not only seriously affected the health of the human respiratory system, but also the potential impact on other systems, especially the nervous system. Studies have shown that severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection may lead to peripheral nervous system damage and neuropathic pain, in which mitochondrial dysfunction is considered to be an important mechanism. Therefore, this paper focuses on the mitochondrial mechanism involved in neuropathic pain caused by SARS-CoV-2 infection, in order to provide a new theoretical basis for exploring the treatment strategy of novel coronavirus infection. In-depth discussion in this research field will help to deepen the understanding of the impact of viruses on the nervous system, and provide new implications for disease treatment and rehabilitation in the future.