三氧水灌肠辅助治疗对早中期膝骨关节炎患者疼痛和生活质量的影响

The effect of adjuvant therapy with ozonated water enema on pain and quality of life in patients with early and middle stage knee osteoarthritis

摘要:

目的:探讨三氧水灌肠辅助治疗对早中期膝骨关节炎患者疼痛和生活质量的影响。方法:选取2023年12月至2024年3月在上海市东方医院疼痛科就诊的早中期膝骨关节炎患者为研究对象,采用随机数字表法分为药物治疗组(对照组)和药物治疗联合三氧水灌肠组(三氧组),每组各35例。对照组采用口服非甾体类抗炎药止痛治疗；三氧组则是在对照组治疗的基础上加用三氧水灌肠治疗。比较两组患者治疗前后的数字评分法 (numeric rating scales,NRS) 评分、超敏C反应蛋白(hypersensitive c reactive protein,hs-CRP)、白细胞介素-6 (Interleukin-6, IL-6)、肿瘤坏死因子-α (Tumor necrosis factor-α, TNF-α)、生活质量评分(the MOS item short from health survey, SF-36),并记录不良反应发生率。结果:69例患者最终完成试验,三氧组有1例患者脱落。和对照组相比,三氧组患者在治疗后1周、2周和4周的NRS评分下降更为显著(P < 0.05),三氧组患者在治疗后其血清IL-6和TNF-α水平下降程度高于对照组,而SF-36评分表(躯体疼痛、生理功能、生理职能、活力、社会功能、情感职能、精神健康、总体健康)评分在治疗后则高于对照组,差异均有统计学意义(P<0. 05),治疗期间两组患者不良反应发生率的差异无统计学意义。结论:在药物治疗基础上加用三氧水灌肠治疗早中期膝骨关节炎可显著缓解患者的疼痛,减轻患者炎症水平,提高其生活质量,为早中期膝骨关节炎患者提供安全有效且无创的辅助治疗方案。

Abstract:

Objective:? To explore the effects of adjuvant therapy with ozonsted water enema on pain and quality of life in patients with early and middle stage knee osteoarthritis. Methods: From December 2023 to March 2024, patients with early and middle stage knee osteoarthritis treated at Department of Pain of East Hospital, Affiliated to Tongji University were randomly assigned to two groups: one for drug treatment (control group) and another for drug treatment combined with ozonated water enema (ozone group), with 35 cases in each group. Oral non-steroidal anti-inflammatory medication was administered to the control group in order to relieve pain; the patients in ozone group were treatde with ozonated water enema on the basis of the control group treatment. The two groups" pre- and post-treatmentnumeric rating scales (NRS) scores, hypersensitivity CRP (hs-CRP), interleukin-6 (IL-6) (tumor necrosis factor-α; TNF-α), and quality of life scores（SF-36） were compared, and any negative reactions were noted. Results: 69 individuals finished the trial; one patient in the group receiving ozonated water enemas fell off. At one，two, and four weeks after treatment, the NRS scores in the ozone group declined more dramatically than in the control group (P < 0.05). The ozone group experienced a greater decrease in hs-CRP, IL-6, and TNF-α compared with the control group. The SF-36 score scale (physical pain, physiological function, physiological function, vitality, social function, emotional function, mental health, overall health) scored higher in ozone group than in the control group, and the differences were statistically significant (P < 0. 05). Conclusion: Ozonate water enema can be added to drug treatment for early and middle stage knee osteoarthritis to significantly relieve pain, reduce inflammation, enhance quality of life, and offer a non-invasive, safe, and effective adjuvant treatment plan for painful knee osteoarthritis.