偏头痛与睡眠-觉醒障碍互作机制的研究进展

Current understanding of the interaction mechanism between migraine and sleep-wake disorder

摘要:

偏头痛是常见的慢性发作性脑功能障碍疾病,具有高疾病负担和高失能性。睡眠障碍和昼夜节律紊乱是偏头痛发生发展进程中的重要影响因素,偏头痛发作具有昼夜节律异质性,且睡眠质量下降往往与偏头痛发作频率增加或慢性化有关。内源性昼夜节律的破坏或其与外部环境之间的失衡可能会导致昼夜节律相关的睡眠-觉醒障碍,这可能导致后续的疼痛过敏,从而使人们罹患偏头痛的风险增高。本综述集中关注偏头痛如何扰乱睡眠以及睡眠觉醒障碍和昼夜节律紊乱如何促进偏头痛这两方面,并阐述了偏头痛和昼夜节律紊乱及睡眠-觉醒调节障碍潜在的共同解剖定位、分子和互作机制。

Abstract:

Migraine is a common chronic paroxysmal brain dysfunction disease with high disease burden and disability. Sleep disorder and circadian rhythm disorder are important influencing factors in the occurrence and development of migraine. Migraine attacks have circadian rhythm heterogeneity, and the decline of sleep quality is often related to the increase or chronicity of migraine attacks. The destruction of endogenous circadian rhythm or its imbalance with the external environment may lead to sleep wake disorders related to circadian rhythm, which may lead to subsequent pain allergy, thus increasing the risk of migraine. This review focuses on how migraine disturbs sleep and how sleep disorder and circadian rhythm disorder promote migraine, briefly introduces circadian rhythm and sleep-wake regulation, and expounds the potential common anatomical location, molecular and interaction mechanism of migraine and circadian rhythm disorder and sleep-wake regulation disorder.