神经病理性疼痛与焦虑共病的神经环路机制研究进展*

Research Progress on the mechanism of neural circuits in the comorbidity of neuropathic pain and anxiety

摘要:

神经病理性疼痛不仅给患者的工作和生活带来严重负担,而且患者更易伴有焦虑等情绪障碍。但既往大多关于神经病理性疼痛与焦虑的研究都将二者独立区分。随着光遗传和化学遗传技术的普及,为精准靶控特定的神经环路以探索神经病理性疼痛与焦虑共病的中枢机制提供了技术支持。大量研究表明在神经病理性疼痛与焦虑共病状态下,中枢神经系统会发生功能重塑。因此,本文将神经病理性疼痛与焦虑共病作为一个整体对其相关神经环路研究进展进行综述,旨在为精准医疗的实施提供理论依据。

Abstract:

Neuropathic pain not only poses a significant burden on patients" work and daily life, but individuals with neuropathic pain are also more likely to experience emotional disorders such as anxiety. However, most previous studies on neuropathic pain and anxiety have distinguished them independently. With the popularity of optogenetic and chemogenetic techniques, precise targeting of specific neural circuits provides technical support for exploring central mechanisms of the comorbidity of neuropathic pain and anxiety. Numerous studies have shown that the central nervous system undergoes functional remodeling in the comorbidity of neuropathic pain and anxiety. This article reviews the neural circuits related to the comorbidity of neuropathic pain and anxiety as a whole, aiming to provide theoretical basis for the implementation of precision medicine.