昼夜节律性疼痛介质的振荡及其在针刺镇痛中的作用

Oscillations of circadian rhythmic pain mediators and their role in acupuncture analgesia

摘要:

疼痛的节律性普遍存在，而时间药物疗法在镇痛方面的推广存在困难。针刺作为一种非药物镇痛疗法，具有成本低、疗效佳、无成瘾等优势，研究表明针刺对节律性疼痛疾病具有明确镇痛效果，针刺可能通过抑制胶质细胞活化，调节神经递质释放等机制发挥镇痛效应。且择时针刺在镇痛的同时能发挥整复节律的作用。与节律性疼痛相关的介质如：星形胶质细胞、小胶质细胞、P物质等，它们参与昼夜节律振荡，并在疼痛信号的传递和疼痛节律性的表达上产生了关键作用。本文就节律性疼痛疾病中相关介质在昼夜振荡中的关系以及这些细胞分子在针刺镇痛过程中发挥的作用进行综述，从时间节律角度出发探讨针刺镇痛原理，以期为阐明针刺镇痛的作用机制提供新的视角。

Abstract:

The rhythmic nature of pain is prevalent, and there are difficulties in the promotion of chronopharmacological therapies for analgesia. Acupuncture, as a kind of non-pharmacological analgesic therapy, hasthe advantages of low cost, good efficacy, and non-addiction, etc. Studies have shown that acupuncture has a clear analgesic effect on rhythmic pain disorders, and that acupuncture may exert an analgesic effect by inhibiting glial cell activation, regulating neurotransmitter release, and other mechanisms. Acupuncture may play an analgesic effect by inhibiting glial cell activation, regulating neurotransmitter release and other mechanisms, and selective acupuncture can play the role of restoring the rhythm while analgesia. Mediators associated with rhythmic pain, such as astrocytes, microglia, and substance P, are involved in circadianoscillations and play a key role in pain signaling and the expression of pain rhythmicity. In this paper, we review the relationship between the relevant mediators in circadian oscillations in rhythmic pain disorders and the roles played by these cellular molecules in the process of acupuncture analgesia, and explore the principle of acupuncture analgesia from the perspective of temporalrhythms, with the aim of providing new perspectives for elucidating the mechanism of action of acupuncture analgesia.