TRPV1在糖尿病神经病理性疼痛中的研究进展

Research progress of TRPV1 in diabetic neuropathic pain

摘要:

近年来，糖尿病（diabetes mellitus，DM）患病率在世界范围内大幅上升，并且DM特异性并发症的发生率较高。糖尿病神经病理性疼痛（diabetic neuropathic pain，DNP）是DM的一种常见并发症，其发病机制尚不明。瞬时感受器电位香草酸亚型 1（transient receptor potential vanilloid subfamily 1, TRPV1）是一种离子通道蛋白，参与热和化学物质等刺激的信号转导。越来越多的研究表明，TRPV1在DNP的发生中起着重要作用。本文综述了TRPV1通道的生理功能，总结了TRPV1通道在DNP中的作用，为DNP的治疗提供新思路。

Abstract:

In recent years, the prevalence of diabetes mellitus (DM) has increased dramatically worldwide, and the incidence of DM-specific complications is high. Diabetic neuropathic pain (DNP) is a common complication of DM, and its pathogenesis is unknown. Transient receptor potential vanilloid subfamily 1 (TRPV1) is an ion channel protein involved in signal transduction by thermal and chemical stimuli. More and more studies have shown that TRPV1 plays an important role in the occurrence of DNP. This article reviews the physiological functions of TRPV1 channels and summarizes the role of TRPV1 channels in DNP, so as to provide new ideas for the treatment of DNP.