慢性疼痛中内质网应激机制的研究进展

Research Progress on Endoplasmic Reticulum Stress Mechanisms in Chronic Pain

摘要:

慢性疼痛作为长期影响患者生活质量的重大公共卫生问题，其复杂的发病机制导致当前治疗策略面临诸多挑战。近年来，内质网应激，即细胞内质网稳态失衡的现象，在慢性疼痛研究领域受到了广泛瞩目。本研究系统性地回顾了内质网应激中内质网蛋白激酶样内切割酶（PKR-like endoplasmic reticulum kinase, PERK）、内质网应激调节因子1α（inositol-requiring enzyme 1α, IRE1α）和激活转录因子6（Activating Transcription Factor 6, ATF6）通路在慢性疼痛中的具体作用机制，探讨了其与疼痛感受、伤害性信号传递、炎症反应和神经可塑性改变的关联。通过深入理解内质网应激在慢性疼痛中的作用，旨在为慢性疼痛的治疗提供新的策略和方法，以期改善患者的生活质量并减轻医疗体系的负担。

Abstract:

Chronic pain, as a significant public health issue with long-term impacts on patients' quality of life, poses numerous challenges to current treatment strategies due to its complex pathogenesis. In recent years, endoplasmic reticulum stress, characterized by imbalanced cellular homeostasis, has garnered widespread attention in the field of chronic pain research. This study systematically reviews the specific mechanisms of endoplasmic reticulum stress, focusing on the pathways involving PKR-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1α (IRE1α), and Activating Transcription Factor 6 (ATF6), and their roles in chronic pain. The association of these pathways with pain perception, nociceptive signaling, inflammatory responses, and neural plasticity changes is discussed. By gaining deeper insights into the role of endoplasmic reticulum stress in chronic pain, the aim is to provide novel strategies and approaches for the treatment of chronic pain, with the ultimate goal of improving patients' quality of life and alleviating the burden on healthcare systems.