交感神经系统参与骨质疏松发病的研究进展

Research progress of sympathetic nervous system involved in osteoporosis

摘要:

骨质疏松症是全球范围内的重大骨骼健康问题，骨组织与神经系统的相互作用对骨骼健康至关重要。大量的临床和基础研究使人们关注交感神经系统对骨质疏松的影响，并已证实交感神经张力增高对骨质量以及骨小梁的微结构和功能是有害的。因此，我们对交感神经系统在骨质疏松发病机制中扮演的角色作一综述，总结交感神经影响骨质疏松的多种分子机制，并从不同角度去考察交感神经在不同类型骨质疏松中的作用，为骨质疏松的防治提供新思路。

Abstract:

Osteoporosis is a major bone health problem worldwide, and the interaction between bone tissue and the nervous system is crucial for bone health. A large number of clinical and basic studies have focused attention on the impact of the sympathetic nervous system on osteoporosis, and it has been confirmed that increased sympathetic nerve tone is harmful to bone quality and the microstructure and function of bone trabeculae. Therefore, we reviewed the role of the sympathetic nervous system in the pathogenesis of osteoporosis, summarized the various molecular mechanisms of the sympathetic nerve affecting osteoporosis, and investigated the role of the sympathetic nerve in different types of osteoporosis from different angles, providing new ideas for the prevention and treatment of osteoporosis.