椎间孔及浅筋膜内注射自体血浆治疗带状疱疹后神经痛

Treatment of postherpetic neuralgia by injecting autologous plasma into the intervertebral foramen and superficial fascia

摘要:

目的 探讨椎间孔及浅筋膜内注射三氧活化的自体血浆治疗带状疱疹后神经痛（Postherpetic Neuralgia, PHN）的疗效和安全性。方法 选取2023年5月4日至2023年7月14日北京中医药大学东方医院疼痛科（二）就诊的PHN患者共30例，所有患者均接受受损侧对应椎间孔及浅筋膜内注射三氧活化的自体血浆治疗。记录所有患者的治疗疗效和不良反应，同时比较治疗前及治疗后1周、治疗后2周、治疗后1个月疼痛数字评分（Numerical Rating Scale, NRS）、焦虑自评量表（Self-rating Anxiety Scale, SAS）、抑郁自评量表（Self-Rating Depression Scale, SDS）、匹兹堡睡眠质量指数（Pittsburg Sleep Quality Index，PSQI）及生活质量评分（Quality of Life, QOL）量表评分。结果 所有患者的治疗总有效率为93.33%，无不良反应和不良事件发生。治疗后1周、治疗后2周及治疗后1个月，所有患者的NRS、SAS、SDS及PSQI总体评分均明显低于治疗前，差异有统计学意义（P < 0.001）；QOL总体评分均明显高于治疗前，差异有统计学意义（P < 0.001）；组内各时间点比较差异也有统计学差异（P < 0.001）。结论 椎间孔及浅筋膜内注射三氧活化的自体血浆治疗带状疱疹后神经痛疗效显著，且无不良反应和不良事件，可以明显缓解带状疱疹后神经痛患者疼痛程度，有效改善其情绪状态、提升患者的睡眠及生活质量，安全性较高。

Abstract:

Objective:We aim to investigate the effectiveness and safety of injection of autologous plasma activated with ozone into the intervertebral foramen and superficial fascia for the treatment of postherpetic neuralgia（PHN）.Methods:From May 4, 2023 to June 28, 2023, a total of 30 patients with PHN were selected from the Pain Department(2) of Dongfang Hospital of Beijing University of Chinese Medicine. All patients received treatment with the injection of autologous plasma activated with ozone into their respective intervertebral foramen and superficial fascia on the injuried side. The treatment efficacy and adverse reactions of all patients will be recorded, and the Numerical Rating Scale (NRS), Self-rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), Pittsburg Sleep Quality Index (PSQI), and Quality of Life (QOL) scores will be compared before and after 1 week, 2 weeks, and 1 month of treatment.Results:The overall effective rate of treatment for all patients amounts to 93.33%, with no adverse reactions or events occurring. Following treatment for 1 week, 2 weeks, and 1 month, the overall scores of NRS, SAS, SDS, and PSQI for all patients were significantly reduced compared to those before treatment, with statistically significant differences (P<0.001). The overall score of QOL was significantly higher than before treatment, indicating statistically significant differences (P<0.001). There is also a statistical difference in the comparison of time points within the group(P<0.001).Conclusions:The treatment of postherpetic neuralgia through injection of autologous plasma activated with ozone into the intervertebral foramen and superficial fascia is not only highly effective but also no adverse reactions or events. It can greatly reduce the pain level of patients suffering from postherpetic neuralgia, thereby enhancing their emotional state, sleep, and quality of life, while also boasting high safety.