三氧自体血疗法联合三氧皮下注射辅助治疗老年急性带状疱疹的疗效分析

Analysis of the Efficacy of Ozone autohemotherapy Combined with Subcutaneous Ozone Injection in the Adjunctive Treatment of Acute Herpes Zoster in the Elderly

摘要:

目的： 探讨三氧自体血疗法联合三氧皮下注射在辅助治疗老年急性期带状疱疹中的疗效。方法：选取2023年1月至2023年10月上海市东方医院疼痛科收治的老年急性期带状疱疹60例，随机分为药物治疗组和药物联合三氧治疗组两组，每组各30例。药物治疗组采用口服伐昔洛韦、甲钴胺、普瑞巴林等常规药物治疗（对照组）；药物联合三氧组在对照组治疗的基础上加用三氧自体血疗法联合三氧皮下注射治疗（三氧组）。比较两组患者治疗前后的疼痛视觉模拟评分（visual analogue scale, VAS）、睡眠状况自评量表（self-rating scale of sleep, SRSS）及抑郁-焦虑-压力评分量表（depression anxiety stress scale, DASS），并记录两组患者的疱疹愈合时间、不良反应发生率及带状疱疹后神经痛的发病率。结果：60例患者全部完成试验，与对照组相比，三氧组患者治疗后1周、2周和1个月的VAS评分下降更为显著（P < 0.05），三氧组患者治疗后SRSS和DASS量表评分均有显著下降（P < 0.05），三氧组患者的疱疹愈合时间（天数）明显缩短（P < 0.01），三氧组带状疱疹后神经痛的发病率更低（P < 0.05），治疗期间两组患者的不良反应发生率统计学差异（P = 0.55）。结论：三氧自体血疗法联合三氧皮下注射可显著减轻患者疼痛，提高睡眠质量，改善情绪状态，加速疱疹愈合并降低带状疱疹后神经痛的发病率，可为老年急性带状疱疹患者提供安全有效的辅助治疗方案。

Abstract:

Objective: To explore the efficacy of ozone autohemotherapy combined with subcutaneous ozone injection in the adjunctive treatment of acute herpes zoster in the elderly. Methods: 60 cases of elderly patients with acute herpes zoster admitted to the Department of Pain, East Hospital, Shanghai from January to October 2023 were selected and randomly divided into two groups: the drug treatment group and the drug combined with ozone treatment group, with 30 cases in each group. The drug treatment group was treated with conventional drugs such as oral acyclovir, cobamamide, and pregabalin (control group); the drug combined with ozone group was treated with ozone autohemotherapy combined with subcutaneous ozone injection on the basis of the control group treatment (ozone group). The visual analogue scale (VAS) for pain, self-rating scale of sleep (SRSS), and depression anxiety stress scale (DASS) before and after treatment were compared between the two groups, and the healing time of herpes, the incidence of adverse reactions, and the incidence of postherpetic neuralgia were recorded. Results: All 60 patients completed the trial. Compared with the control group, the VAS score of the ozone group was significantly lower at 1 week, 2 weeks, and 1 month after treatment (P < 0.05), and the SRSS and DASS scores of the ozone group were significantly reduced after treatment (P < 0.05). The healing time (days) of herpes in the ozone group was significantly shortened (P < 0.01), and the incidence of postherpetic neuralgia in the ozone group was lower (P < 0.05). There was no statistical difference in the incidence of adverse reactions during treatment between the two groups (P = 0.55). Conclusion: Ozone autohemotherapy combined with subcutaneous ozone injection can significantly relieve pain, improve sleep quality, improve emotional state, accelerate herpes healing, and reduce the incidence of postherpetic neuralgia, providing a safe and effective adjunctive treatment plan for elderly patients with acute herpes zoster.