神经胶质细胞在神经病理性疼痛和抑郁中的作用

Role of neuroglia in neuropathic pain and depression

摘要:

神经病理性疼痛患者常伴随抑郁等情感障碍,形成共病状态。已有研究揭示,神经胶质细胞在中枢及外周神经病理性疼痛的发生与维持中扮演关键角色。同时,亦有证据表明神经胶质细胞参与了抑郁症的发病过程。尽管如此,关于神经胶质细胞在神经病理性疼痛和共病抑郁中的具体作用机制,尚未有全面系统的综述。因此,本文系统梳理了近年来神经胶质细胞在神经病理性疼痛和共病抑郁中的相关研究成果。经过综述分析,结果提示神经胶质细胞在神经病理性疼痛与抑郁症共病中起到了桥梁作用。本综述有望为神经病理性疼痛的治疗策略提供新的启示,并为未来的机制研究提供有益参考。

Abstract:

Patients with neuropathic pain often suffer from comorbid emotional disorders such as depression. Previous studies have demonstrated that neuroglia play a crucial role in the generation and persistence of both central and peripheral neuropathic pain. Meanwhile, there is also evidence indicating the involvement of neuroglia in the pathogenesis of depression. Nevertheless, a comprehensive and systematic review of the specific mechanisms of neuroglia in neuropathic pain and depression is still lacking. Therefore, this paper systematically reviews the relevant research achievements of neuroglia in neuropathic pain and comorbid depression in recent years. Through this analysis, we have identified a bridging function of neuroglia in the comorbidity of neuropathic pain and depression. This review is expected to provide new insights into treatment strategies for neuropathic pain and offer valuable references for future mechanistic studies.