疱疹相关性疼痛介入治疗效果与预后的多因素分析

Multivariate analysis of the effect and prognosis of interventional therapy for herpes related pain

摘要:

目的：探讨影响疱疹相关性疼痛(zoster-associated pain,ZAP)疗效的因素。方法：回顾性分析2019年1月至2021年10月接受微创介入治疗的111例ZAP患者的基线特征及治疗方法,并进行随访。术后3个月NRS改善程度≥50%定义为有效。采用单因素Kaplan-Meier法分析和多因素Cox回归分析以确定影响ZAP疗效的因素。结果：单因素分析显示病程(P =0.004)、微创介入治疗方法(脉冲射频、标准射频、低温等离子消融术)(P =0.004)与ZAP疗效显著相关。多因素Cox回归分析中,病程被确定为ZAP疗效的独立预后因素(P＜0.05)。结论：病程是ZAP疗效的独立预后因素,适应证患者应早期进行微创介入治疗,有利于减轻患者疼痛,提高其生活质量。

Abstract:

Objective: To explore the factors affecting the efficacy of zoster- associated pain (ZAP). Methods: The baseline characteristics and treatment methods of 111 ZAP patients who received invasive interventional treatment from January 2019 to October 2021 were retrospectively analyzed and followed up. An improvement of NRS ≥50% 3 months after surgery was defined as effective. Univariate Kaplan-Meier analysis and multivariate Cox regression analysis were used to determine the factors affecting the efficacy of ZAP. Results: Univariate analysis showed that the course of disease (P =0.004 )and treatment method (P =0.004) were significantly related to the efficacy of ZAP. In multivariate Cox regression analysis, disease duration was determined to be an independent prognostic factor for ZAP efficacy (P<0.05). Conclusion: The course of the disease is an independent prognostic factor for the efficacy of ZAP. Early intervention can help reduce patients" pain to a greater extent and improve their quality of life.