基于病毒载体的神经性疼痛靶向基因治疗*

Targeted gene therapy for neuropathic pain based on viral vectors

摘要:

神经病理性疼痛(neuropathic pain, NP)一直是临床上的重要课题。然而NP的止痛效果往往不理想。NP的产生涉及到了多种病理生理机制，而基因治疗作为一种新兴的策略，也已经被人们广泛研究。大量的研究表明，病毒载体介导的基因治疗能够缓解NP模型的疼痛，提示其可能是未来治疗疼痛的有效方法之一。本文将重点讨论基于病毒载体用来缓解NP的基因治疗，不同靶点的基因治疗为将来NP的临床试验提供了有益的参考。

Abstract:

Neuropathic pain (NP) has always been an important clinical issue. However, the pain relief effect of NP is often unsatisfactory. The generation of NP involves a variety of pathophysiological mechanisms, and gene therapy, as an emerging strategy, has been widely studied. Numerous studies have demonstrated that viral vector-mediated gene therapy can alleviate pain in NP models, suggesting that it may be one of the effective methods for treating pain in the future. In this paper, we will focus on gene therapy based on viral vectors used to alleviate NP, and gene therapy with different targets provides a useful reference for future clinical trials in NP.