Abstract:OBJECTIVE: To retrieve the best evidence for perioperative pain management in older patients. Methods: Based on the "6S" evidence model, a top-down search was performed on Up To Date, BMJ Best Clinical Practice, Australian JBI Centre for Evidence-Based Health Care database, Canadian Nursing Association of Ontario (RNAO), Association of Registered Nurses in Perioperative Surgery (AORN), National Institute for Healthcare Optimisation (NICE), Guidelines International Network (GIN), Chinese Guidelines Network, Cochrane Library, CINA, CINA, and the National Institute for Healthcare Excellence (NIHE) in England. (NICE), Guidelines International Network (GIN), China Guidelines, Cochrane Library, CINAHL, PubMed, China Knowledge, and Wanfang databases related to perioperative pain management in older patients, including clinical decisions, guidelines, evidence summaries, systematic reviews, expert consensus, and related information. We also searched the Cochrane Library, CINAHL, PubMed, China Knowledge and WanWei databases for evidence related to perioperative pain management in elderly patients, including clinical decisions, guidelines, evidence summaries, systematic evaluations, expert consensus, and relevant original studies. The search timeframe was from the construction of the database to 11 October 2023. Two researchers independently assessed the quality of the literature and combined professional judgement to extract and summarise evidence from the literature that met the criteria. RESULTS: A total of eight papers were included, including two expert consensus papers, one evidence summary, three guidelines, one systematic evaluation, and one position statement. Ultimately, 18 best evidence items were summarised in 4 areas: pain management principles, pain assessment, intervention strategies, and pain management and education. CONCLUSION: This study summarises the current literature related to postoperative pain in elderly patients and provides an evidence-based basis for clinical pain management in elderly patients, and clinical staff should use the evidence based on the best clinical evidence and the actual medical situation in hospitals in order to improve the quality of care.