综述持续性躯体形式疼痛障碍的发病机制*

The pathogenesis of persistent somatoform pain disorder.

摘要:

持续性躯体形式疼痛障碍 (persistent somatoform pain disorder, PSPD)是临床一项比较常见且复杂的疾病,是“躯体形式障碍”的一个亚型,患者通常反复就诊、疗效不定且高度焦虑。PSPD的发病机制目前尚不明确,暂无特效药物,临床治疗多以抗抑郁药物、抗精神病药物等药物治疗为主,联合心理疗法。本文回顾总结了近年来PSPD在神经生理机制方面的研究进展,以期为明确PSPD的发病机制提供参考。

Abstract:

Persistent somatoform pain disorder (PSPD) is a common and complex clinical disease and a subtype of somatoform disorder. Patients usually have repeated visits, uncertain treatment outcomes, and high levels of anxiety. The pathogenesis of PSPD is not yet clear, there are no specific drugs, and clinical treatment is mostly based on antidepressant drugs, antipsychotic drugs and other drug treatment, combined with psychotherapy[1]. In this paper, we review and summarize the recent research progress of PSPD in neurophysiological mechanisms, in order to provide reference for clarifying the pathogenesis of PSPD.