△通讯作者：曹君利[e-mail]

The research progress on the involvement of the thalamic limbic system in the chronicity of acute pain

摘要:

疼痛是一种复杂的感觉和情绪情感体验。急性疼痛避免机体过度受伤，而长期持续的疼痛可能会发展为慢性疼痛。慢性疼痛的发病率逐年上升，影响了超过15%的世界人口，严重增加了社会经济负担。近年来，随着脑成像技术的进步，急性疼痛慢性化的神经环路机制得到广泛的研究。本文从神经影像学和动物实验模型相结合的角度，阐述了从疼痛的感觉-识别（丘脑）到情绪-情感（边缘系统）相关大脑区域在急性疼痛慢性化中的潜在变化，为开发理想的慢性疼痛治疗方案提供见解。

Abstract:

Pain represents a complex sensory and emotional phenomenon. Acute pain acts as a physiological warning, indicating the necessity to prevent severe injury, while persistent pain has the potential to evolve into a chronic condition. The yearly incidence of chronic pain is steadily increasing, impacting over 15% of the global populace and imposing a substantial socioeconomic burden. In recent years, thanks to advancements in brain imaging technology, extensive research has been conducted to explore the neural circuit mechanisms that modulate the chronicity of acute pain. Employing a dual approach that integrates neuroimaging and animal experimental models, this article elucidates modifications within cerebral regions, ranging from pain sensory perception (thalamus) to emotional processing (limbic system), consequently furnishing invaluable insights to inform the development of optimal therapeutic strategies for chronic pain.