慢性内脏痛及诱发负性情绪的神经环路研究进展

Neural circuits of negative emotions induced by chronic visceral pain

摘要:

慢性内脏痛及其诱发的负性情绪严重影响了患者的生活质量，并产生巨大的社会经济成本。然而，与其相关的神经环路和机制仍是尚未解决的生命科学难题。前扣带回和杏仁核是处理啮齿类动物和人类慢性疼痛感觉和情绪成分的核心脑区，因此，在这篇综述中，我们以慢性内脏痛中功能性胃肠疾病（肠易激综合征）为例，重点围绕上述核团，从神经环路水平，总结并分析肠易激综合征啮齿类动物模型内脏痛及诱发负性情绪脑环路的最新发现。同时，我们还讨论了今后该研究领域相关的重要研究方向，为揭示慢性内脏痛及诱发负性情绪的机制研究提供新线索。

Abstract:

Chronic visceral pain and its induced negative emotional reactions seriously affect the quality of life of patients and have a huge socio-economic cost. However, its related neural circuits and mechanisms are still unsolved life science problems. The anterior cingulate cortex and amygdala are the core brain regions that process the sensory and emotional components of chronic pain in rodents and humans. Therefore, in this review, we took functional gastrointestinal disease (irritable bowel syndrome) as an example, focusing on the above nuclei, and explored the latest findings of visceral pain and its negative emotional responses in rodent models of irritable bowel syndrome from the level of neural circuits. At the same time, we also discussed the important research directions related to this research field in the future, and provided new clues for revealing the mechanism of chronic visceral pain and inducing negative emotions.