半月神经节周围注射不同形态和浓度三氧治疗三叉神经痛的疗效研究

Efficacy of Different Concentrations of Gaseous Ozone and Ozonated Water Injection Around Gasserian Ganglion on the Patient with Trigeminal Neuralgia*

摘要:

目的：比较不同形态和浓度三氧半月神经节注射治疗三叉神经痛的疗效。方法：收集2016年11月至2021年11月因三叉神经痛接受治疗的病人诊疗信息,按接受三氧注射的不同形态和浓度分为23 μg/ml液态三氧组23例, 30 μg/ml气态三氧组31例,40 μg/ml气态三氧组17例；治疗后1周、6个月和1年进行随访。采用视觉模拟评分法(visual analogue scale, VAS)评分、巴罗神经学研究所 (Barrow neurological institute, BNI)疼痛评分、von Frey试验评估病人疼痛程度和面部触觉。结果：与治疗前相比,三组在不同时间点的VAS,BNI评分均显著降低,治疗后1周30 μg/ml气态三氧组VAS,BNI评分显著低于其余两组,治疗后6个月和1年组间差异无统计学意义。同样,与治疗前相比,术后von Frey值也显著降低(P<0.05),但组间差异无统计学意义。结论：发现23 μg/ml液态三氧,30 μg/ml和40 μg/ml气态三氧半月神经节注射治疗均可显著缓解三叉神经痛。23 μg/ml液态三氧注射治疗的潜在并发症风险小,临床应用价值更大。

Abstract:

Objective: This study aimed to assess the effects of different concentrations of gaseous and liquid ozone injection around gasserian ganglion on the patient with trigeminal neuralgia. Methods: Collected the data of patients who suffered from Trigeminal neuralgia pain from 2016 to 2021, then divided into 23 μg/ml ozonated water injection group of 23 patients, 30 μg/ml gaseous ozone injection group of 31 patients, 40μg/ml gaseous ozone injection group of 17 patients according to the different concentrations of gaseous ozone and ozonated water. The therapeutic efficacy was evaluated via visual analog scale (VAS), Barrow Neurological Institute (BNI) pain score and tactile sensation at pre-treatment, post-treatment, 6 months and 1 year. Results: The VAS and BNI scores in the three groups at different time points were significantly lower than pre-treatment (P < 0.05). Compared with 23 μg/ml ozonated water injection and 40 μg/ml gaseous ozone injection groups, the VAS, and BNI scores of the 30 μg/ml gaseous ozone injection group were lower 1 week after treatment (P < 0.05). Similarly, the tactile sensation was significantly decreased at post-treatment compared to pre-treatment (P < 0.05). However, there were no statistical differences among the three groups. Conclusion: 23 μg/ml ozonated water injection, 30 μg/ml gaseous ozone injection and 40 μg/ml gaseous ozone injection are effective therapies for treating TN. 23 μg/ml ozonated water injection has a lower risk of potential complications and more excellent value in clinical applications.