神经—免疫通讯在疼痛中的作用研究进展*

Research progress on the mechanism of neuro-immune crosstalk in pain*

摘要:

疼痛是临床最常见的综合征之一，其发生机制复杂，严重影响患者生活质量。近年来，研究发现疼痛的产生与免疫细胞释放的炎性物质，以及外周和中枢神经元敏化密切相关。进一步的研究表明，神经系统与免疫系统之间密切关联、相互作用，形成了对疼痛的感知与调节环路，共同参与疼痛的发生发展。本文旨在对疼痛中免疫细胞和伤害性感受神经元之间的双向调控进行综述，以期揭示疼痛背后的神经—免疫通讯机制，并为探索防治疼痛的新型靶点提供理论依据。

Abstract:

Pain is one of the most common clinical syndromes, which mechanism is complex, severely affects the life quality of patients. Recent studies have revealed that pain is correlated with the inflammatory substance released by immune cells, as well as the sensitization of peripheral and central nervous system. Further researches indicate a close interaction between the nervous system and the immune system, forming a perception and regulatory loop for pain, collectively contributing to the occurrence and development of pain. Aiming to uncover the neuro-immune crosstalk mechanisms of pain, this article reviews the bidirectional regulation between immune cells and nociceptive neurons, thus providing theoretical basis for exploring new targets for pain prevention and treatment.