Abstract:Objective: To explore the short-term efficacy and complications of extracranial radiofrequency thermocoagulation (ERT) and percutaneous balloon compression (PBC) in the treatment of primary trigeminal maxillary branch pain. Methods: The clinical data of patients treated for primary trigeminal maxillary pain from 2020 to 2021 were retrospectively collected. They were divided into ERT group (n=29) and PBC group (n=31). Barrow Neurological Institute (BNI) pain scores, numerical ratings scale (NRS) and complications were assessed at 1 day, and 1, 3 and 6 months after surgery. Results: A total of 60 cases were included. There were no significant differences in gender, age, pain side, course of disease, BNI and NRS before treatment and within 6 months after treatment between the two groups (P>0.05). At the 6th month, there was still 1 case of hearing loss, 2 cases of eye complications, and 1 case of masticatory muscle weakness in the PBC group, while no cases were found in the ERT group (P>0.05). There was no significant difference in the incidence of facial numbness between the two groups in the first 3 months (P>0.05). However, there was significantly higher in the ERT group at 6 months than in the PBC group (P<0.05). Conclusion: Short term efficacy of ERT in the treatment of primary trigeminal maxillary branch pain is comparable to PBC. The PBC group has more complications. ERT produces longer-lasting facial numbness.