鞘内给药治疗慢性疼痛的研究进展*

Research progress on intrathecal drug delivery for chronic pain

摘要:

目前,慢性疼痛(Chronic pain)已被定义为一种疾病,全球众多患者受其困扰,口服镇痛药等常规治疗方法效果不佳且副作用大。通过鞘内给药(Intrathecal drug delivery, ITDD)技术,药物可以经给药系统注入蛛网膜下腔,由脑脊液循环直接作用于脑、脊髓而发挥作用,达到快速、稳定、高效的治疗慢性疼痛的目的,同时其低药物剂量减少了药物副作用,改善了患者生活质量及心理状态。笔者就当前鞘内给药治疗慢性疼痛的研究进展做一综述,以期为当下利用ITDD治疗慢性疼痛及后续ITDD的改进完善提供思路。

Abstract:

Nowadays, chronic pain has been defined as a disease that afflicts a large number of patients around the world. Conventional treatments (such as oral analgesics) have poor efficacy and great adverse effects. Intrathecal drug delivery (ITDD) is a technique in which drugs are injected into the subarachnoid space through the drug delivery system. And then, drugs directly act on the brain and spinal cord through the circulation of cerebrospinal fluid, which can treat chronic pain quickly, stably and efficiently. The low drug dose of ITDD can reduce side effects and enhance the quality of life and psychological state of patients. In this article, we reviewed the latest research progress on ITDD for chronic pain, in order to provide ideas for the treatment of chronic pain by ITDD and subsequent studies about the improvement of ITDD.