神经胶质细胞参与吗啡耐受的研究进展

The role of glial cells in the development of morphine tolerance

摘要:

吗啡镇痛效果显著，常用于慢性或剧烈性疼痛的治疗，但重复给药会发生镇痛效能降低并进展为吗啡耐受导致治疗中断，极大限制其临床应用。吗啡耐受的细胞和分子机制复杂。近年来，胶质细胞的激活和胶质细胞源性炎症介质的释放被发现在这一过程中发挥了重要作用。本文围绕神经胶质细胞参与并调控吗啡耐受的研究进展进行综述并总结新的治疗手段，为解决吗啡耐受问题或开发新型镇痛药物提供可能的思路与理论依据。

Abstract:

Morphine has a significant analgesic effect and is commonly used in the treatment of chronic or severe pain. However, repeated administration can lead to reduced analgesic efficacy and progression to morphine tolerance leading to treatment interruption, which greatly limits its clinical application. Cellular and molecular mechanisms of morphine tolerance are complex. In recent years, activation of glial cells and release of glial cell-derived inflammatory mediators have been found to play an important role in this process. In this paper, we review the research progress of glial cells involved in and regulating morphine tolerance and summarize new therapeutic methods. To provide possible ideas and theoretical basis for solving morphine tolerance or developing new analgesic drugs.