基于代谢组学视角下的神经病理性疼痛研究进展

Advances in neuropathic pain from the perspective of metabonomics

摘要:

神经病理性疼痛（neuropathic pain，NP）是指在感觉神经系统受到损伤或疾病而引起的慢性疼痛。目前NP发病机制尚不完全清楚，对于NP的治疗也仅限于疼痛症状的管理，严重影响患者的生活质量并给社会带来巨大的经济负担。代谢组学研究是现代生物学研究的一门新兴学科，通过检测病理刺激或基因修饰下细胞、组织或器官代谢产物，筛选差异性代谢产物，反向探究疾病的代谢及信号通路，发现潜在病理机制和治疗靶点。目前神经病理性疼痛的代谢组学研究已产生了极大进展，开辟了神经病理性疼痛机制研究新视角，产生了大量成果。但目前相关综述报道较少。因此，本文通过综述代谢组学相关技术及神经病理性疼痛的代谢组学进展，旨在归纳分析代谢组学视角下NP发生发展的病理机制及潜在治疗靶点。

Abstract:

Neuropathic pain (NP) is chronic pain caused by injury or disease of the sensory nervous system. At present, the pathogenesis of NP is not completely clear, and the treatment of NP is only limited to the management of pain symptoms, which seriously affects the quality of life of patients and brings a substantial economic burden to society. Metabonomics research is a new subject in modern biological research. It can detect the metabolic products of cells, tissues, or organs under pathological stimulation or gene modification, screen differential metabolic products, reverse explore diseases' metabolism and signal pathways, and find potential pathological mechanisms and therapeutic targets. At present, the metabonomic study of neuropathic pain has made great progress, opened up a new perspective for the study of neuropathic pain mechanism, and produced a lot of results. However, there are few relevant review reports at present. Therefore, this article aims to summarize and analyze the pathological mechanism and potential therapeutic targets of NP from the perspective of metabonomics by reviewing metabonomic-related technologies and the progress of metabonomics in neuropathic pain.