催产素与催产素受体系统的镇痛作用及机制研究进展

The research progress in the analgesic effect and mechanism of oxytocin and oxytocin receptor system

摘要:

疼痛是一种与组织损伤或潜在组织损伤相关的不愉快的主观感觉和情感体验。全球疼痛患者数量逐年增长，但临床上治疗疼痛的有效手段仍有所欠缺。因此，进一步寻找安全有效的新型镇痛策略迫在眉睫。已知催产素是具有多种生理和社会功能的一种下丘脑神经肽，除经典的催产、泌乳等效应外，它在疼痛调节中的作用得到了人们的关注。它发挥强大镇痛作用的一个关键模式是存在于中枢和外周神经系统广泛联系的催产素及催产素受体所组成的神经网络系统所介导，但具体镇痛机制尚未研究透彻。本文将简要介绍催产素与催产素受体，并就近年来其在疼痛相关的临床前和临床研究进展展开综述，梳理催产素与催产素受体系统参与镇痛的相关机制，揭示其对疼痛治疗的价值。

Abstract:

Pain is an unpleasant subjective sensory and emotional experience associated with tissue damage or the underlying tissue damage. The number of patients worldwide suffering from pain is increasing year by year, but clinically effective means to treat pain are still lacking. Therefore, it is urgent to further find safe and effective novel analgesic strategies. It is known that oxytocin is a hypothalamic neuropeptide with various physiological and social functions, and its role in pain regulation has gained spiked attention besides the classical effects such as deliver and lactation. A key pattern of its potent analgesic effects is mediated by a neural network system composed of oxytocin and oxytocin receptors that are widely linked in the central and peripheral nervous systems, but the specific analgesic mechanisms remain unclear. This paper will briefly introduce oxytocin and oxytocin receptor, and review its preclinical and clinical research progress in pain in recent years, comb through the mechanisms involved of oxytocin and oxytocin receptor system in analgesia, and reveal its value for pain treatment.