半月神经节电刺激治疗三叉神经区带状疱疹相关性疼痛

Effect of Trigeminal Ganglion Stimulation for Trigeminal herpes zoster-associated pain

摘要:

目的：分析使用半月神经节电刺激治疗三叉神经区带状疱疹相关性疼痛（Zoster-Associated Pain, ZAP）的安全性和有效性。方法：收集2021年1月至2021年12月在河南省人民医院疼痛科行半月神经节电刺激的三叉神经区带状疱疹患者，观察术后短期及长期疼痛数字评分（Numeric rating scales, NRS），治疗有效率（较治疗前疼痛缓解> 50%）及术后不良反应。结果：本研究共纳入19例患者，术前疼痛NRS为（6.4 ± 1.3）分,电刺激平均留置时间为（5.2 ± 1.3）天，电极拔除后疼痛NRS为（2.8 ± 1.1）分，治疗有效率为73.7%，治疗后较治疗前疼痛程度明显降低，差异有统计学意义（P < 0.05）。术后所有患者均未发生严重不良反应。远期随访的中位随访时间为70天（ 范围为28～370天），截至最后一次随访，18例患者疼痛完全缓解（NRS ≤ 3）。结论：半月神经节电刺激可快速缓解三叉神经区ZAP，不良反应发生率低，远期疗效好，是治疗三叉神经区ZAP安全有效的治疗措施。

Abstract:

Objective This study aimed to evaluate the efficacy and safety of Trigeminal Ganglion Stimulation for the treatment of trigeminal herpes zoster-associated pain (ZAP). Methods Patients diagnosed with Trigeminal herpes zoster at the Department of Pain Management, Henan Provincial People's Hospital between January 2021 and December 2021were selected. Numerical pain scales and complications were analyzed during short-term stimulation and long-term follow-up. Treatment effectiveness was defined as pain relief of more than 50%. Results A total of 19 patients were enrolled. The NRS before surgery was 6.4±1.3, the mean indwelling time of the electrode was 5.2 ± 1.3 days, the NRS of pain after electrode removal was 2.8±1.1. The effective rate was 73.7%. The pain severity after treatment was significantly lower than that before treatment (P < 0.05). No serious complications occurred in all patients. The median follow-up time of was 70 days (range 28-370 days). By the last follow-up, 18 patients had complete remission (NRS ≤ 3), with a complete remission rate of 94.7%. Conclusion Trigeminal ganglion stimulation can relieve trigeminal ZAP quickly. The incidence of complications was low and long-term efficacy was good. It is a safe and effective treatment for trigeminal ZAP.