Abstract:[Abstract] Herpes zoster (HZ) is a skin disease mainly manifested by regional rash and severe painerythema, papules, pimples and pain due to the replication and distribution of neurotropic varicella-zoster virus (VZV) along the nerves due to low immunity in the human body, which can affect any peripheral nerve distributionsurface parts of the body. The most common complication of HZ is postherpetic neuralgia (PHN), which is a refractory chronic pain disease, causing great burden on patients' psychology, physiology and economy. Although the pathogenesis of HZ is still unclear, a large number of studies have shown that itsIts occurrence and development are closely related to the immune regulation of the body, involving the interaction of various immune cells and cytokines. immune regulation and involve the activation of various immune cells, tissue cells and cytokines. A variety of Different cytokines play anti-inflammatory, pro-inflammatory, anti-viral and promote cell proliferation and differentiation functions, and jointly regulate body immunity. However, no scholars have summarized the specific changes and functions of cytokines caused by the onset of HZ. This review mainly elaborated the change rules and potential clinical significance of related cytokines during HZ onset after VZV infection, in order to find out the HZ-specific expression factors or factors that can predict PHN from existing studies. In addition, some potential therapeutic targets have been explored from the biological functions of these differentially expressed factors, and new ideas have been provided for future mechanism studies.
