A型肉毒毒素治疗周围神经病理性疼痛的应用进展

Application of botulinum toxin A in peripheral neuropathic pain

摘要:

周围神经病理性疼痛（peripheral neuropathic pain，pNP）如带状疱疹后神经痛、痛性糖尿病周围神经病变等，常引起睡眠障碍、焦虑、抑郁等不良结果，严重影响患者生活质量，也给社会带来相应的经济负担。随着人口老龄化，其发病率逐年增高。经研究表明，A型肉毒毒素可用于治疗多种pNP，本文归纳总结了国内外近年来的相关文献，阐述了A型肉毒毒素治疗常见周围神经病理性疼痛的机制、有效性及安全性等。

Abstract:

Peripheral neuropathic pain (pNP), such as postherpetic neuralgia and painful diabetic peripheral neuropathy, often causes adverse outcomes such as sleep disturbance, anxiety, depression, and brings economic burdens to patients and society. With the aging of the population, its incidence increases year by year. Studies have shown that botulinum toxin-A can be used as a treatment for most pNPs. This paper summarizes the relevant literature at home and abroad in recent years, and expounds the mechanism, effectiveness and security of botulinum toxin-A in the treatment of common peripheral neuropathic pain.