Abstract:Neuropathic pain (NP) is a common pain condition, mainly caused by injury of the nervous system. There are still difficulties in the diagnosis and treatment of NP, and its pathogenesis needs to be further explored. Proteomics is a technology that identifies, analyzes and quantitatively acquires the composition of all proteins in the target tissue, widely used in the research on pathological mechanisms, biomarkers, drug targets, etc. This paper provides a review of the current researches on proteomics in NP. In basic researches, significant changes in protein levels are found in metabolic enzymes, signal transduction, and oxidative stress in animal models of NP.In clinical researches, it was found that diseases, such as postherpetic neuralgia, lead to significant changes in protein levels in oxidative stress and mitogen-activated protein kinase pathways (MAPK pathways)，and also in extracellular matrix proteins. Proteomics researches provide important information for further investigation on the pathogenesis and therapeutic targets of NP by screening out the differences in protein expression in specific directions.
