草乌甲素治疗带状疱疹急性疼痛的疗效分析

ANALYSIS OF THE EFFICACY OF BULLEYACINITINE A ON ACUTE HERPETIC PAIN

摘要:

摘 要 目的: 观察口服草乌甲素 (bulleyacinitine A, BLA) 治疗带状疱疹急性疼痛的疗效。方法: 将带状疱疹急性期疼痛病人100例按照就诊先后顺序分为对照组和治疗组（每组50例），两组病人均给予相同的常规治疗，治疗组在常规治疗的基础上给予口服BLA。观察和记录两组病人治疗前、治疗后第1周、2周、3周、4周的疼痛视觉模拟评分 (visual analogue scale, VAS)、睡眠质量 (quality of sleep, QS) 评分、治疗有效率以及带状疱疹后神经痛 (postherpetic neuralgia, PHN) 的发生率。结果: 与治疗前比较，两组病人治疗后各时间点的VAS评分和QS评分均显著降低 (P < 0.05)；与对照组相比，治疗组VAS评分和QS评分变化更为明显 (P <0.05)；治疗组在治疗后第1周、2周的有效率显著高于对照组，同时PHN的发生率与对照组相比明显降低 (P < 0.05)。结论: 早期口服BLA对带状疱疹急性期的疼痛具有显著缓解作用，可以缩短疼痛时间，提高病人睡眠质量，降低PHN的发生率，且无明显不良反应，具有一定的临床应用价值。

Abstract:

Abstract Objective: To observe the effect of oral bulleyacinitine A (BLA) on acute herpetic pain. Methods: A total of 100 patients with acute herpetic pain were divided into control group and treatment group (50 cases in each group) according to the order of treatment. Both groups were given the same conventional treatment, and the treatment group was given oral BLA on the basis of conventional treatment. Visual analogue scale (VAS) score and quality of sleep (QS) score of 2 groups were observed and recorded before treatment and at week 1, 2, 3 and 4 after treatment. The effective rate and the incidence of postherpetic neuralgia (PHN) in both groups was recorded. Results: Compared with before treatment, VAS score and QS score of 2 groups at each time point after treatment were significantly decreased (P < 0.05). Compared with the control group, the changes of VAS score and QS score in the treatment group were more obvious (P < 0.05). The effective rate in the treatment group was significantly higher than that in the control group at 1 and 2 weeks after treatment, and the incidence of PHN was significantly lower than that in the control group (P < 0.05). Conclusion: Oral BLA can significantly relieve the pain in the acute stage of herpes zoster, improve the sleep quality of patients and reduce the incidence of PHN, without obvious adverse reactions, which has certain clinical application value.