氢吗啡酮治疗癌性骨痛临床效果及对 血清TNF-α和IL-6的影响

Clinical effect of hydromorphone in the treatment of bone cancer pain and the effects of serum TNF-α and IL-6

摘要:

摘要：目的：探讨盐酸氢吗啡酮注射液皮下镇痛泵治疗中、重度癌性骨痛的镇痛效果，以及对血清TNF-α和IL-6浓度的影响。方法：采用回顾性研究的方法，选取2020年1月至2021年3月应用盐酸氢吗啡酮注射液皮下镇痛泵治疗癌性骨痛病例57例，其中中度癌性骨痛组26例，重度癌性骨痛组31例，收集一般信息并比较两组治疗前后镇痛效果及血清TNF-α和IL-6浓度变化。结果：两组经盐酸氢吗啡酮注射液皮下镇痛泵治疗后疼痛明显缓解（P<0.05），血清TNF-α和IL-6浓度较治疗前下降（P<0.05）。结论：盐酸氢吗啡酮注射液皮下镇痛泵治疗中、重度癌性骨痛效果较好，且两组患者治疗后血清TNF-α及IL-6浓度降低。

Abstract:

Abstract：Objective: To explore the analgesic effect of hydromorphone hydrochloride injection subcutaneous analgesic pump in the treatment of moderate and severe bone cancer pain, and its effect on the density of serum TNF-α and IL-6. Methods: A retrospective study was used to select 57 cases of bone cancer pain treated with hydromorphone hydrochloride injection subcutaneous analgesic pump from January 2020 to March 2021, including 26 cases in the moderate bone cancer pain group and 31 cases in the severe bone cancer pain group, collect general information，compare the analgesic effect and serum TNF-α and IL-6 density of the two groups before and after treatment. Results: The pain of the two groups was significantly relieved after treatment with hydromorphone hydrochloride injection subcutaneous analgesic pump (P<0.05), and the expression levels of TNF-α and IL-6 were lower than before treatment (P<0.05). Conclusion: The hydromorphone hydrochloride injection subcutaneous analgesic pump is effective in treating moderate and severe bone cancer pain, and the serum TNF-α and IL-6 density of the two groups of patients decreased after treatment.