椎间盘内注射富血小板血浆对比射频热凝治疗盘源性腰痛的临床研究*

CLINICAL STUDY OF INTRADISCAL INJECTION OF PLATELET-RICH PLASMA VERSUS RADIOFREQUENCY THERMOCOAGULATION IN THE TREATMENT OF DISCOGENIC LOW BACK PAIN

摘要:

目的：比较椎间盘内注射富血小板血浆与射频热凝术治疗盘源性腰痛的作用。 方法：采用随机对照试验设计,67例盘源性腰痛患者随机分为治疗组(PRP组)37例和对照组30例(RFT组),其中PRP组接受盘内注射富血小板血浆,RFT组接受射频热凝术。两组于治疗前、治疗后1周及、3周及1年,进行视觉模拟疼痛评分(VAS评分)、脊柱功能指数评分(FRI评分)及简明健康调查问卷评分(SF-36)。比较两组在上述指标、治疗有效率及安全性方面的差异。结果：两组患者的FRI评分在各个时间点比较差异均无统计学意义；治疗后1年,PRP组VAS评分及SF-36评分较RFT组有显著降低(P<0.05),且PRP组有效率明显高于RFT组(P<0.05)。结论：椎间盘内注射富血小板血浆较射频热凝术对盘源性腰痛具有更显著的作用。

Abstract:

Objective: To compare the effects of intradiscal injection of platelet-rich plasma and radiofrequency thermocoagulation in the treatment of discogenic low back pain. Methods: Using a randomized controlled trial design, 67 patients with discogenic low back pain were randomly divided into a treatment group (PRP group) with 37 cases and a control group with 30 cases (RFT group). In which PRP group treated with PRP intradiscal injection, and RFT group treated with radiofrequency thermocoagulation. The two groups were evaluated for visual analog pain scores (VAS scores), spinal function index scores (FRI scores) and short-form health questionnaire scores(SF-36) at baseline, 1 week, 3 weeks and 1 year after treatment. To compare the differences between the two groups in the above indicators, treatment efficiency and safety. Results: There was no significant difference in FRI scores between the two groups at each time point (P>0.05). One year after treatment, the VAS score and SF-36 score in the PRP group were significantly lower than those in the RFT group (P<0.05). And the curative rate of PRP group was significantly higher than that of RFT group (P<0.05). Conclusion: Intradiscal injection of platelet-rich plasma has a more significant effect on discogenic low back pain than radiofrequency thermocoagulation.