Abstract:Objective: To investigate the effectiveness and safety of modified inferior endplate direct method in the treatment of L5/S1 lumbar disc herniation via percutaneous interlaminar endoscopic discectomy.Methods: 42 patients with L5/S1 intervertebral disc herniation were treated with modified inferior endplate direct method (lower endplate direct method after visual circular saw to expand the lamina space) via percutaneous interlaminar endoscopic discectomy between June 2020 and December 2020.They were followed up for 6M,the postoperation neurological function and pain status was evaluated by the visual analog scale (VAS) and the Oswestry disability indox (ODI),The patients'satisfaction was evaluated by the Modified macnab criteria, and the complications during follow-up were recorded.Results All 42 patients completed the operation successfully, one patient recurred after 3M, and all patients completed the postoperative follow-up. The ODI index and pain VAS score at 5 days, 1M, 3M and 6m were significantly lower than those before operation (P < 0.05). Six months after operation, the patients'satisfaction was evaluated according to modified macnab standard: excellent in 22 cases, good in 17 cases and fair in 2 cases. The excellent and good rate was 92.9%; There were 7 patients with paresthesia after operation, 3 patients still had paresthesia at the follow-up of 1 month after operation, and 1 patient had paresthesia at the follow-up of 6 months after operation. It was observed that 3 patients had nerve root injury, no patient had dural sac injury, and no other serious complications.Conclusion it is safe and effective to treat L5/S1 segment intervertebral disc herniation by modified inferior endplate direct method.