小胶质细胞介导脊髓损伤后神经病理性疼痛机制研究

THE MECHANISMS OF MICROGLIAL IN MEDIATING NEUROPATHIC PAIN AFTER SPINAL CORD INJURY

摘要:

脊髓损伤后神经病理性疼痛是脊髓损伤患者常见的并发症，其发生机制复杂，给临床治疗带来巨大的挑战。越来越多证据表明小胶质细胞通过扩大神经炎症反应介导脊髓损伤后神经病理性疼痛。本文以神经炎症为切入点，对小胶质细胞参与脊髓损伤后神经病理性疼痛过程机制进行综述，期待为治疗脊髓损伤后神经病理性疼痛带来新思路。

Abstract:

Neuropathic pain after spinal cord injury is a common complication in patients with spinal cord injury, which brings great challenges to clinical treatment due to the complex mechanism. More and more evidence suggested that microglia is involved in neuropathic pain after spinal cord injury by promoting the neuroinflammation. In this paper, the mechanism of microglia involved in neuropathic pain after spinal cord injury was reviewed from the perspective of neuroinflammation, and we hope to bring new ideas for the treatment of neuropathic pain after spinal cord injury.