白介素1在炎症性关节痛中的表达及临床意义

The expression and clinical significance of interleukin 1 in inflammatory joint pain

摘要:

目的：探讨炎症性关节痛（inflammatory joint pain）患者血清中白介素1（interleukin 1）的表达水平及临床意义。方法：根据纳入和排除标准选取初次就诊我院的炎症性关节痛患者31例纳入试验组，同时选取初次就诊我院的年龄、性别等基本信息与试验组相匹配的非炎症性关节痛患者31例、机械压迫痛（椎管狭窄、椎间盘突出）患者31例及年龄、性别均匀分布的健康人80名为对照组，其中炎症性关节痛患者、非炎症性关节痛患者及机械压迫痛患者疼痛视觉模拟评分法 (visual analogue scale, VAS)评分均大于或等于4分，健康人群评分均为0分。使用ELISA试剂盒检测上述两组人群血清中白介素1的含量。结果：（1）非炎症性关节痛患者、机械压迫痛患者及正常人群血清中C反应蛋白（C-reactive protein）和红细胞沉降率（erythrocyte sedimentation rate）均在正常值范围内，白介素1的含量处于较低水平；（2）炎症性关节痛患者血清中C反应蛋白、红细胞沉降率及白介素1的含量明显高于上述对照组。结论：血清中白介素1可能是炎症性关节痛特异的生物标志物，可与患者体征、C反应蛋白以及红细胞沉降率等综合判断关节痛是否由炎症引起的，从而对炎症性关节痛进行及早诊断和治疗。

Abstract:

Objective: To investigate the expression and clinical significance of interleukin-1 in the serum of patients with inflammatory joint pain. Methods: According to the inclusion and exclusion criteria, 31 patients with inflammatory joint pain who visited our hospital for the first time were recruited in the experimental group. 31 patients with non-inflammatory joint pain who matched basic information of the experimental group such as age and gender, 31 patients with mechanical compression pain (spinal canal stenosis, intervertebral disc herniation) and 80 healthy people were recruited in the control group. Patients with inflammatory joint pain, non-inflammatory joint pain and mechanical compression pain were all ≥ 4 points using visual analogue scale, and the scores of healthy people were all 0 points. ELISA kits were used to detect the levels of interleukin-1 in the serum of the two groups of people. Results: (1) Values of serum C-reactive protein and erythrocyte sedimentation rate in patients with non-inflammatory joint pain, mechanical compression pain and normal people were in the normal range, and the content of interleukin 1 was at a low level; (2) The content of C-reactive protein, erythrocyte sedimentation rate and interleukin-1 in the serum of patients with inflammatory joint pain was significantly higher than control group. Conclusion: Serum interleukin 1 is possibly a new biomarker of inflammatory joint pain. Together with patient's physical signs, C-reactive protein and erythrocyte sedimentation rate, interleukin 1 can be used to diagnosis inflammatory joint pain. Thus, inflammatory joint pain can be diagnosed early and corresponding treatment can be carried out as soon as possible.